Bio availability
Bio availability is the proportion of an administered drug that reaches the systemic circulation and is therefore available for distribution to the intended site of action.
Drugs that are given by direct IV injection are said to have 100% bioavailability. Some drugs that are particularly well absorbed by the gastrointestinal mucosa may have bio availability comparable to that of an IV dose – for example the antibiotic ciprofloxacin. Most drugs do not have this availability by the oral route so the dose given orally is usually higher than that given parenterally. For example, the beta-blocker propranolol when given orally is administered in doses of 40mg and above. The equivalent IV dose is 1mg.The route of administration and its formulation (tablet, capsule, liquid) can clearly influence the bio availability of a drug.
Routes of administration
There are various routes of administration available, each of which has associated advantages and disadvantages. All the routes of drug administration need to be understood in terms of their implications for the effectiveness of the drug therapy and the patient’s experience of drug treatment.
Routes of administration
Bio availability is the proportion of an administered drug that reaches the systemic circulation and is therefore available for distribution to the intended site of action.
Drugs that are given by direct IV injection are said to have 100% bioavailability. Some drugs that are particularly well absorbed by the gastrointestinal mucosa may have bio availability comparable to that of an IV dose – for example the antibiotic ciprofloxacin. Most drugs do not have this availability by the oral route so the dose given orally is usually higher than that given parenterally. For example, the beta-blocker propranolol when given orally is administered in doses of 40mg and above. The equivalent IV dose is 1mg.The route of administration and its formulation (tablet, capsule, liquid) can clearly influence the bio availability of a drug.
Routes of administration
There are various routes of administration available, each of which has associated advantages and disadvantages. All the routes of drug administration need to be understood in terms of their implications for the effectiveness of the drug therapy and the patient’s experience of drug treatment.
Routes of administration
- Oral
- Sub lingual
- Rectal
- Topical
- Parenteral – Intravenous, intramuscular, subcutaneous