Rosuva
Why is this medication prescribed?
Rosuva is used together with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Rosuva is also used to decrease the amount of cholesterol and other fatty substances in the blood in adults and children at least 10 years of age. Rosuva is in a class of medications called HMG-CoA reductase inhibitors . It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.
What side effects can this medication cause?
Rosuva may cause side effects.
Distribution
Mean volume of distribution at of rosuva is approximately 134 liters. Rosuva is 88% bound to plasma proteins, mostly albumin . This binding is reversible and independent of plasma concentrations.
Metabolism
Rosuva is not extensively metabolized; approximately 10% of a radiolabeled dose is recovered as metabolite. The major metabolite is N-desmethyl rosuvastatin, which is formed principally by cytochrome P450 2C9. Overall, greater than 90% of active plasma reductase inhibitory activity is accounted for by the parent compound.
Excretion
Following oral administration, rosuva and its metabolites are primarily excreted in the feces (90%). The elimination half-life (t½) of rosuvas is approximately 19 hours.
Why is this medication prescribed?
Rosuva is used together with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Rosuva is also used to decrease the amount of cholesterol and other fatty substances in the blood in adults and children at least 10 years of age. Rosuva is in a class of medications called HMG-CoA reductase inhibitors . It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.
What side effects can this medication cause?
Rosuva may cause side effects.
- constipation
- heartburn
- dizziness
- difficulty falling asleep or staying asleep
- depression
- joint pain
- cough
- memory loss or forgetfulness
- confusion
- muscle pain, tenderness, or weakness
- lack of energy
- fever
- chest pain
- yellowing of the skin or eyes
- dark colored urine
- pain in the upper right part of the abdomen
- nausea
- extreme tiredness
- weakness
- unusual bleeding or bruising
- loss of appetite
- flu-like symptoms
- sore throat, chills, or other signs of infection
- rash
- hives
- itching
- difficulty breathing or swallowing
- swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
- hoarseness
- numbness or tingling in fingers or toes
Distribution
Mean volume of distribution at of rosuva is approximately 134 liters. Rosuva is 88% bound to plasma proteins, mostly albumin . This binding is reversible and independent of plasma concentrations.
Metabolism
Rosuva is not extensively metabolized; approximately 10% of a radiolabeled dose is recovered as metabolite. The major metabolite is N-desmethyl rosuvastatin, which is formed principally by cytochrome P450 2C9. Overall, greater than 90% of active plasma reductase inhibitory activity is accounted for by the parent compound.
Excretion
Following oral administration, rosuva and its metabolites are primarily excreted in the feces (90%). The elimination half-life (t½) of rosuvas is approximately 19 hours.